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NanoBiology:

NanoBone is a unique and patented advanced bone grafting material designed to be used as a standalone graft. It incorporates nano-crystalline particles of hydroxyapatite (HA), which are essentially identical to HA particles occurring in human bone, in an amorphous silica gel (ASG).

In NanoBone SBX Putty, we have a product that combines Applied NanoBiology for bone repair with perfect handling for the surgeon. NanoBone SBX Putty has the same Indications for Use as NanoBone Granules, that is, as a bone void filler for use in the treatment of surgically created osseous defects or defects resulting from traumatic injury to bone.

To extend the usability of NanoBone, we put the perfect handling of NanoBone SBX Putty in an applicator designed for QD – quick delivery. This easy-to-use device facilitates rapid implantation of our advanced bone graft in a controlled and precise manner. Artoss developed NanoBone QD to provide these benefits in a cost-effective delivery system.

NanoBone is a unique and patented advanced bone grafting material. It incorporates nano-crystalline particles of hydroxyapatite (HA) that are similar in size, chemistry, and morphology to HA particles occurring in human bone. Most synthetic bone graft products use very large particles (1-3 mm) of bioceramic as the basis of their product. Although the body recognizes the chemistry of some of these products, the size is foreign. The body struggles to remodel these large bioceramic particles because they are 100,000 times the size of naturally occurring HA.

Nanocrystalline Hydroxyapatite (HA)

• ▪ Similar size, chemistry, and morphology as HA in human bone
• ▪ No bonding between nanocrystals - unsintered
• ▪ Autologous proteins adsorb rapidly to surface

Amorphous Silica Gel Matrix (ASG)

• ▪ Highly nanoporous with large internal surface area
• ▪ Holds HA nanocrystals in place
• ▪ Extremely hydrophilic
• ▪ Releases SiO2 triggering angiogenesis, the basis for bone formation
• ▪ Is rapidly replaced by autologous organic matrix

NanoBone consists of nanocrystals of hydroxyapatite (HA) dispersed in an amorphous silica gel matrix (ASG). The HA nanocrystals have similar size, chemistry, and morphology to the HA in human bone. These nanocrystals are not bound to one another and autologous proteins adsorb rapidly to the surface.

The ASG that holds the HA nanocrystals in place is highly nanoporous with an extremely large internal surface area that attracts autologous proteins that are critical for new bone formation. ASG is also very hydrophilic and releases silicon dioxide, which triggers angiogenesis and new bone formation.

Post-implantation, release of SiO2 triggers angiogenesis, enhances osteoblastic differentiation, and stimulates bone formation3. Silica gel is transformed into an osteogenic scaffold. Once the organic matrix is in place, osteogenesis and remodeling proceed.

Following implantation, the amorphous silica gel is rapidly replaced by an autologous organic matrix. Once the organic matrix is in place, the process of cell-mediated bone formation and resorption proceeds.